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Decellularized bSIS-ECM as a Regenerative Biomaterial for Skin Wound Repair

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Skin Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1879))

Abstract

Tissue engineering-based regenerative applications can involve the use of stem cells for the treatment of non-healing wounds. Multipotent mesenchymal stem cells have become a focus of skin injury treatments along with many other injury types owing to their unprecedented advantages. However, there are certain limitations concerning the solo use of stem cells in skin wound repair. Natural bioactive extracellular matrix-based scaffolds have great potential for overcoming these limitations by supporting the regenerative activity and localization of stem cells. This chapter describes the use of bone marrow mesenchymal stem cells together with decellularized bovine small intestinal submucosa (SIS), for the treatment of a critical-sized full-thickness skin defect in a small animal model.

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Competing Interests

The authors have intellectual properties related to decellularized tissues. Y.M.E. is the founder and director of Biovalda, Inc. (Ankara, Turkey).

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Authors and Affiliations

  1. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University, Faculty of Science and Stem Cell Institute, Ankara, Turkey

    Mahmut Parmaksiz & Ayşe Eser Elçin

  2. Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University, Faculty of Science, Ankara, Turkey

    Yaşar Murat Elçin

  3. Biovalda Health Technologies, Inc., Ankara, Turkey

    Yaşar Murat Elçin

Authors
  1. Mahmut Parmaksiz
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  2. Ayşe Eser Elçin
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  3. Yaşar Murat Elçin
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Corresponding author

Correspondence to Yaşar Murat Elçin .

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Editors and Affiliations

  1. Ottawa, ON, Canada

    Kursad Turksen

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© 2018 Springer Science+Business Media New York

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Parmaksiz, M., Elçin, A.E., Elçin, Y.M. (2018). Decellularized bSIS-ECM as a Regenerative Biomaterial for Skin Wound Repair. In: Turksen, K. (eds) Skin Stem Cells. Methods in Molecular Biology, vol 1879. Humana Press, New York, NY. https://doi.org/10.1007/7651_2018_147

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  • DOI: https://doi.org/10.1007/7651_2018_147

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8869-3

  • Online ISBN: 978-1-4939-8870-9

  • eBook Packages: Springer Protocols

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