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Application of Decellularized Tissue Scaffolds in Ovarian Tissue Transplantation
In tissue engineering, decellularized scaffolds have been proved to have remarkable capacity to promote regeneration in various organs such as kidney, heart, lung, and liver. Marrying the field of cryobiology and reproductive medicine resulted in considerable progress and breakthroughs, which led to the emergence of ovarian tissue cryopreservation and transplantation as a promising option for fertility preservation. Here we describe an innovative application of decellularized tissue scaffolds as a regenerative platform for reconstruction of ovarian grafts for auto-transplantation.
Keywords:Cryopreservation Decellularized tissue scaffold Extracellular tissue matrix Fertility preservation Ovarian tissue transplantation
K.O. is supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD—RO1HD053112 and R21HD061259) and National Cancer Institute (NCI).
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