Abstract
Decellularization technology promises to overcome some of the significant limitations in the regenerative medicine field by providing functional biocompatible grafts. The technique involves removal of the cells from the biological tissues or organs for further use in tissue engineering and clinical interventions. There are significant differences between decellularization protocols due to the intrinsic properties of different tissue types and purpose of use. This multistep, chemical-solution-based protocol is optimized for the preparation of decellularized bovine small intestinal submucosa (SIS).
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Competing Interests
Y.M.E. is the founder of Biovalda, Inc. (Ankara, Turkey) and has intellectual properties related to decellularized tissues.
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Parmaksiz, M., Elçin, A.E., Elçin, Y.M. (2017). Decellularization of Bovine Small Intestinal Submucosa. In: Turksen, K. (eds) Decellularized Scaffolds and Organogenesis. Methods in Molecular Biology, vol 1577. Humana Press, New York, NY. https://doi.org/10.1007/7651_2017_33
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DOI: https://doi.org/10.1007/7651_2017_33
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