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Type 1 Diabetes: Current Perspectives

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Type-1 Diabetes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1433))

Abstract

Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic susceptibility factors are decreasing in frequency as the incidence of the condition increases. This suggests a growing role for environmental determinants but these have been difficult to identify and our understanding of gene/environment effects are limited. Individuals “at risk” can be identified accurately through the presence of multiple islet autoantibodies and current efforts in type 1 diabetes research focus on improved biomarkers and strategies to prevent or reverse the condition through immunotherapy.

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Authors and Affiliations

  1. Diabetes and Metabolism Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Bristol, UK

    Aizhan Kozhakhmetova & Kathleen M. Gillespie

Authors
  1. Aizhan Kozhakhmetova
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  2. Kathleen M. Gillespie
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Corresponding author

Correspondence to Kathleen M. Gillespie .

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Editors and Affiliations

  1. Diabetes and Metabolism Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Bristol, United Kingdom

    Kathleen M. Gillespie

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Kozhakhmetova, A., Gillespie, K.M. (2015). Type 1 Diabetes: Current Perspectives. In: Gillespie, K. (eds) Type-1 Diabetes. Methods in Molecular Biology, vol 1433. Humana Press, New York, NY. https://doi.org/10.1007/7651_2015_289

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  • DOI: https://doi.org/10.1007/7651_2015_289

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3641-0

  • Online ISBN: 978-1-4939-3643-4

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