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Biomimetic Strategies Incorporating Enzymes into CaP Coatings Mimicking the In Vivo Environment

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Biomimetics and Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1202))

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Abstract

Biomimetic calcium phosphate coating (CaP) methodology mimics the natural biomineralization process of bone, which involves two phases: nucleation and growth. In this chapter we present a successful method to coating biodegradable natural-origin materials with biomimetic CaP layer as a strategy to incorporate enzymes with the main aim of controlling and tailoring their degradation over time. This strategy seems to enhance the bone-bonding, osteoconductive, and osteoinductive properties of natural-origin biomaterials that per se do not present these characteristics.

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Acknowledgements

A.M.M. acknowledges “Fundação para a Ciência e Tecnologia” (FCT) for the Postdoctoral grant (SFRH/BPD/66897/2009) financed by POPH-QREN-Advanced Formation, and co-financed by Social European Fund and National Fund from MCTES.

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Authors and Affiliations

  1. 3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Caldas das Taipas, Guimarães, 4806-909, Portugal

    Ana M. Martins & Rui L. Reis

Authors
  1. Ana M. Martins
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  2. Rui L. Reis
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Corresponding authors

Correspondence to Ana M. Martins or Rui L. Reis .

Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering and Department of Medicine, Columbia University, New York, New York, USA

    Gordana Vunjak-Novakovic

  2. Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

    Kursad Turksen

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© 2013 Springer Science+Business Media New York

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Martins, A.M., Reis, R.L. (2013). Biomimetic Strategies Incorporating Enzymes into CaP Coatings Mimicking the In Vivo Environment. In: Vunjak-Novakovic, G., Turksen, K. (eds) Biomimetics and Stem Cells. Methods in Molecular Biology, vol 1202. Humana Press, New York, NY. https://doi.org/10.1007/7651_2013_53

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  • DOI: https://doi.org/10.1007/7651_2013_53

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1331-2

  • Online ISBN: 978-1-4939-1332-9

  • eBook Packages: Springer Protocols

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