Antibiotic Resistance Evaluation of Yersinia pestis
Yersinia pestis is the causative agent of plague and has the potential for use as a biological weapon. Y. pestis clinical isolates that are resistant to all antimicrobial agents recommended for plague therapy have been found. Therefore, standardized methods should be established to detect emerging drug-resistant Y. pestis strains. In this chapter, three microbial susceptibility testing methods (disk diffusion, E test, and broth microdilution) are introduced, including the Clinical and Laboratory Standards Institute reference method for susceptibility testing of Y. pestis (broth microdilution).
Key wordsYersinia pestis Disk diffusion E test Broth microdilution
- 3.Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: 19th informational supplement. M100-S19 CLSI, Wayne, PA 2009, 29(3)Google Scholar