Animal Models for Yersinia pestis
Many animal models have now been developed to mimic the course of Yersinia pestis infection. These models are useful for understanding, defending against, and treating plague. Studies have indicated that rodent and nonhuman primate models of pneumonic plague closely resemble human disease, and pathologic changes that occur in rodents, nonhuman primates, and humans during bubonic plague are very similar. Thus, classic model organisms, such as mouse and monkey, are still widely used for different purposes. This section describes Y. pestis infection in mouse via subcutaneous, intravenous, intraperitoneal, and intranasal routes or in monkeys via subcutaneous and intravenous routes. The protocols described in this chapter require special handling conditions for infected animals, and very close attention should be given to the specific recommendations for animal care with each infectious agent.
Key wordsYersinia pestis Animal model Mouse Monkey
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