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Xenograft Mouse Models for Tumour Targeting

  • Colin GreenEmail author
  • Hakim Djeha
  • Gail Rowlinson-Busza
  • Christina Kousparou
  • Agamemnon A. Epenetos
Protocol
  • 1.8k Downloads
Part of the Springer Protocols Handbooks book series (SPH)

Abstract

Identification and development of new monoclonal antibodies and other biological molecules such ad Fab fragments, diabodies and peptides is a key focus of many biotechnology and pharmaceutical companies and academic research department in several therapeutic areas, including oncology, autoimmune disease and infection. Before commencing clinical trials with such products, it is often essential to assess the targeting and/or efficacy effects that are desirable for such biological molecules as well as the potential for off-target effects as a result of non-specific uptake. Here we describe some of the methods that may be used to investigate labeled proteins and similar biological molecules

Keywords

Human Tumour Xenograft Disodium EDTA Instant Thin Layer Chromatography Measure Tumour Volume Relative Tumour Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Colin Green
    • 1
    Email author
  • Hakim Djeha
    • 1
  • Gail Rowlinson-Busza
    • 1
  • Christina Kousparou
    • 2
  • Agamemnon A. Epenetos
    • 2
    • 3
  1. 1.Antisoma Research LtdBioPark HertfordshireWelwyn Garden CityUK
  2. 2.Trojantec LtdThe Bank of Cyprus Oncology CentreNicosiaCyprus
  3. 3.Imperial College LondonLondonUK

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