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Haplotype Association Mapping in Mice

  • Shirng-Wern Tsaih
  • Ron Korstanje
Protocol
Part of the Methods in Molecular Biology™ book series (MIMB, volume 573)

Abstract

Haplotype Association Mapping (HAM) is a novel phenotype-driven approach to identify genetic loci and was originally developed for mice. This method, which is similar to Genome-Wide Association (GWA) studies in humans, looks for associations between the phenotype and the haplotypes of mouse inbred strains, treating inbred strains as individuals. Although this approach is still in development, we review the current literature, present the different methods and applications that are in use, and provide a glimpse of what is to come in the near future.

Key words

Haplotypes association mice 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Shirng-Wern Tsaih
    • 1
  • Ron Korstanje
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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