Organic Acids by Ion Chromatography

  • William E Rich
  • Edward Johnson
  • Louis Lois
  • Brian E. Stafford
  • Pokar M. Kabra
  • Laurence J. Marton
Part of the Biological Methods book series (BM)


The presence of increased levels of various organic acids in physiological fluids such as serum, plasma, and urine has been correlated with a variety of diseases (1). Although some are rare, others such as lactic acidosis and hyperoxaluria are more widespread (2, 3). The estimation of organic acids in biological fluids has long been an analytical problem owing to the nature of the samples and the hydrophilic behavior of the various acids.


Lactic Acidosis Pyruvic Acid Concentrator Column Acid Stock Solution Suppressor Column 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Snyder, L. R., Karger, B. L., and Giese, R. W., Contemp. Top. Anal. Clin. Chem. 2, 230 (1978).Google Scholar
  2. 2.
    Chalmers, R. A., Lawson, A. M., and Borud, D., Clin. Chem. Acta 77, 117 (1977).CrossRefGoogle Scholar
  3. 3.
    Charransol, G., Barthelemy, C., and Peagrey, P., J. Chromatogr. 145, 452 (1978).Google Scholar
  4. 4.
    Goodman, S. I., Helland, P., Stokke, O., and Jellum, E., J. Chromatogr. 141, 497 (1977).Google Scholar
  5. 5.
    Molnar, I., and Horvath, C., J. Chromatogr. 143, 391 (1977).Google Scholar
  6. 6.
    Miyagi, H., Miura, J., Takata, Y., and Canno, S., Clin. Chem. 25, 1617 (1979).Google Scholar
  7. 7.
    Small, H., Stevens, T., and Bauman, W., Anal. Chem. 47, 1801 (1975).CrossRefGoogle Scholar
  8. 8.
    Wheaton, R. W., and Bauman, W. C., Ind. Eng. Chem. 45, 228 (1953).CrossRefGoogle Scholar
  9. 9.
    Turkelson, V. T., and Richards, M., Anal. Chem. 50, 1420 (1978).CrossRefGoogle Scholar
  10. 10.
    Rich, W., Smith, F., McNeill, L., and Sidebottom, T., Ion Exclusion Coupled to Ion Chromatography: Instrumentation and Application, in Ion Chromatographic Analysis of Environmental Pollutants, Vol. 2, Ann Arbor Science Press, Ann Arbor, Michigan, 1979, p. 17.Google Scholar
  11. 11.
    Wittmann, P., Haslbeck, M., Bachmann, W., and Mehnert, M., Deutsch. Med. Wochenschr. 102, 5 (1977).CrossRefGoogle Scholar
  12. 12.
    Afifi, A. A., Chang, P. C., Lin, V. Y., et al, Am. J. Cardiol. 33, 826 (1974).CrossRefGoogle Scholar
  13. 13.
    Laurence, D. R., Clinical Pharmacology, 4th ed., Churchill Livingstone, Edinburgh, 1973, p. 284Google Scholar
  14. 14.
    Sundaram, P. V., and Hinsch, W., Clin. Chem. 25, 285 (1979).Google Scholar

Copyright information

© The Humana Press, Inc. 1981

Authors and Affiliations

  • William E Rich
    • 1
  • Edward Johnson
    • 1
  • Louis Lois
    • 1
  • Brian E. Stafford
    • 2
  • Pokar M. Kabra
    • 2
  • Laurence J. Marton
    • 2
  1. 1.Department of Research and DevelopmentDionex CorporationSunnyvale
  2. 2.Department of Laboratory MedicineUniversity of California, School of MedicineSan Francisco

Personalised recommendations