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Bilirubin and Its Carbohydrate Conjugates

  • Norbert J. C. Blanckaert
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Part of the Biological Methods book series (BM)

Abstract

In mammals, the open tetrapyrrole bilirubin (structure 2, Fig. 1) is the principal degradation product of iron-protoporphyrin-IX (heme). The latter molecule is a tetrapyrrolic macrocycle and plays a critical role in aerobic metabolism by reversibly binding oxygen in hemoglobin and myoglobin, and by serving as the active site in oxidation reactions catalyzed by hemoprotein enzymes. Important cyclic tetrapyrroles in nature related to heme are chlorophylls, which contain magnesium and are derived from protoporphyrin-IX, and vitamin B12, a corrinoid derived from uroporphyrinogen-III.

Keywords

Dimethyl Ester Hepatobiliary Disease Bile Pigment Unconjugated Bilirubin Tetrapyrrolic Macrocycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press, Inc. 1981

Authors and Affiliations

  • Norbert J. C. Blanckaert
    • 1
    • 2
  1. 1.Department of Laboratory Medicine and Liver CenterUniversity of California Medical CenterSan Francisco
  2. 2.Department of Medical Research, Campus GasthuisbergUniversity of LeuvenLeuvenBelgium

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