Principles and Methods of Industrial Metal Carcinogenesis Testing

  • Max Costa
Part of the Biological Methods book series (BM)


A large number of industrial processes use metals in different ways to produce a final product. The risks associated with the use of potentially carcinogenic metals depends upon the factors discussed in the last sections of Chapter 1. These risks are also associated with the industrial process used and the safety measures taken to prevent potential worker exposure. The industrial process should minimize the atmospheric release of aerosols that contain potentially carcinogenic metals and dusts of metal carcinogens. These aerosols are formed during crushing operations in metal refineries or the heating of metal, thus resulting in the vaporization of metal carcinogens during such processes as welding or metal alloy production. If there is a release of metal carcinogens into the atmosphere, for legal and ethical reasons alike these levels must be monitored and exposed workers should consequently be required to wear appropriate respiratory devices to resist inhalation of these...


Metal Compound Microsomal Enzyme Metal Sample Morphological Transformation Carcinogenic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lippmann, M., and R. B. Schlesinger, Chemical Contamination in the Human Environmment. Oxford University Press, New York, 1979.Google Scholar
  2. 2.
    Byus, C. V., M. Costa, I. G. Sipes, B. B. Brodie, and D. H. Russell, Activation of CAMP-dependent Protein Kinase and Induction or Ornithime Decarboxylase as Early Events in Induction of Mixal-Functional Oxygenases, Proc. Natl. Acad. Sci. 73, 1241–1245 (1976).PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1980

Authors and Affiliations

  • Max Costa
    • 1
  1. 1.University of Texas Medical School at Houston

Personalised recommendations