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Molecular Mechanisms of Metal Carcinogenesis in Experimental Animals

  • Max Costa
Protocol
  • 128 Downloads
Part of the Biological Methods book series (BM)

Introduction

The molecular mechanisms of metal carcinogenesis are not well understood. However, the data available suggest that metals cause cancer by a mechanism that is similar to the way in which organic carcinogens induce transformation, i.e., by binding to cellular DNA or associated proteins, which then induce mutations. Whether the metal compound or free metal is converted to an “ultimate” carcinogen is not known, but several different experiments suggest that the ionization state and the crystalline structure of the metal are important factors in determining its ability to cause cancer. If a metal causes cancer by direct “genetic mechanisms” involving mutations in the primary sequency of DNA, it must be able to distribute directly to the nucleus and remain there to make contact with DNA. Experimental evidence suggests that carcinogenic metals do in fact enter the nuclei preferentially, and bind to nucleic acids and proteins within the nuclear structure. Additionally, experiments...

Keywords

Thymidine Kinase Metal Compound Ames Test Carcinogenic Activity Thymidylate Synthetase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1980

Authors and Affiliations

  • Max Costa
    • 1
  1. 1.University of Texas Medical School at Houston

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