Metal Carcinogenesis In Experimental Animals

  • Max Costa
Part of the Biological Methods book series (BM)


Numerous studies have demonstrated that cadmium, cobalt, chromium, and nickel are potent inducers of carcinomas and sarcomas in experimental animals. Other metal compounds that have induced tumors in experimental animals include beryllium, iron, lead, titanium, and zinc. However, the evidence that these latter metal compounds induce cancer is scattered and not very conclusive. The induction of localized tumors in experimental animals at the site of injection has been demonstrated following parenteral administration of the metals themselves, their soluble salts, and various insoluble metal compounds (oxides or sulfides). Comprehensive studies using various combinations of metal compounds have not yet been conducted, and it is therefore very difficult to assess whether specific metal compounds have greater or lower carcinogenic activity than the free metal itself. A possible exception to this situation is found with nickel. The carcinogenic activity of a number of nickel...


Metal Compound Chromium Oxide Cadmium Chloride Carcinogenic Activity Nickel Compound 
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Copyright information

© The Humana Press Inc. 1980

Authors and Affiliations

  • Max Costa
    • 1
  1. 1.University of Texas Medical School at Houston

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