Protein–Protein Interactions

  • Hae Ryoun Park
  • Lisa Montoya Cockrell
  • Yuhong Du
  • Andrea Kasinski
  • Jonathan Havel
  • Jing Zhao
  • Francisca Reyes-Turcu
  • Keith D. Wilkinson
  • Haian Fu
Part of the Springer Protocols Handbooks book series (SPH)

1. Introduction

Diverse cellular processes are mediated by dynamic networks of interacting proteins in living organisms (1,2). These highly regulated protein–protein interactions determine cellular functions that are fundamental to life. As increasing numbers of protein complexes and interconnected protein networks are revealed by a variety of experimental approaches, general principles underlying protein–protein interactions and their roles in controlling cellular processes have emerged. It appears that a general mode of protein–protein interaction is mediated by a diverse group of specialized protein modules within individual proteins (2). These protein modules often contain sequence motifs and structures conserved throughout evolution. The efficient regulation of many protein interactions is achieved in part by posttranslational modification of a specific protein motif, such as phosphorylation of a protein motif generating a new binding site for other proteins. For example, Src...


Protein Interaction Surface Plasmon Resonance Fluorescence Polarization Yellow Fluorescent Protein Bait Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hae Ryoun Park
    • 1
  • Lisa Montoya Cockrell
    • 2
  • Yuhong Du
    • 3
  • Andrea Kasinski
    • 2
  • Jonathan Havel
    • 2
  • Jing Zhao
    • 3
  • Francisca Reyes-Turcu
    • 3
  • Keith D. Wilkinson
    • 3
  • Haian Fu
    • 3
  1. 1.Pusan UniversityNamgu, BusanKorea
  2. 2.Graduate Program of Molecular and Systems PharmacologyEmory University School of MedicineAtlantaGA
  3. 3.Department of PharmacologyEmory University School of MedicineAtlantaGA

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