Rodent Model of Pediatric Asphyxial Cardiac Arrest
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A model of asphyxial cardiac arrest in 17-day old rats is described. This clinically relevant model includes a period of hypoxemia followed by ischemia and resuscitation. Continuous physiologic monitoring is performed before, during, and after the insult. Graded insults produce consistent and dose-dependent brain injury with histological damage and behavioral impairment. The details of the procedures, along with outcome assessments and applications, are discussed.
KeywordsAsphyxia Cardiac arrest Cerebral blood flow Neurodegeneration Sprague-Dawley rat
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- 11.2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Part 6: Paediatric basic and advanced life support. Resuscitation 2005;67(2–3):271–91Google Scholar