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Acute Clip Impact-Compression Model

  • Charles H. Tator
  • Peter Poon
Protocol
Part of the Springer Protocols Handbooks book series (SPH)

In human spinal cord injury, the most common mechanism is the combination of acute impact and continuing compression. To simulate combined impact-compression, we developed in the 1970s the acute clip impact-compression model, one of the first nontransection models in the rodent. Subsequently, we characterized the relationships between clip strength, duration of compression, and neurological recovery, and established dose-response relationships between the forces of clip compression injury, axon-evoked potentials, spinal cord blood flow, neurological function, axon counts, and retrograde labeling of supraspinal neurons with axonal tracers. Clip injury is useful for in vitro and in vivo SCI studies in rats and mice for cervical, thoracic, and lumbar injuries, and is consistent, reliable, and relatively inexpensive.

Keywords

Spinal cord injury Clip impact-compression model Injury mechanisms 

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Copyright information

© Humana Press, a part of Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Charles H. Tator
    • 1
  • Peter Poon
    • 1
  1. 1.Toronto Western HospitalTorontoCanada

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