Controlled Cortical Impact Injury Model

  • C. Edward Dixon
  • Anthony E. Kline
Part of the Springer Protocols Handbooks book series (SPH)

Controlled focal mechanical cortical deformations in rodents have been widely used to model histological, physiological, neurochemical, and functional aspects of human traumatic brain injury. The most common technique termed controlled cortical impact (CCI) utilizes a mechanically actuated piston to control the velocity and depth of cortical impact. In this chapter, we introduce step-by-step procedures to perform a typical CCI in rodents. Details regarding anesthesia, surgery and CCI device operation are included.


Rat Traumatic brain injury Contusion Craniotomy 


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Copyright information

© Humana Press, a part of Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • C. Edward Dixon
    • 1
  • Anthony E. Kline
    • 1
  1. 1.Departments of Neurosurgery, Physical Medicine & Rehabilitation, Psychology, Center for Neuroscience, Brain Trauma Research Center, Center for the Neural Basis of Cognition, and the Safar Center for Resuscitation ResearchUniversity of PittsburghPittsburghUSA

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