Experimental Nerve Plexus Root Avulsion and Spinal Cord Implantation

  • Thomas Carlstedt
  • Mårten Risling
Part of the Neuromethods book series (NM, volume 149)


The nerve plexus is a complicated formation originating from cervical or lumbosacral spinal nerve roots. It has recently attracted considerable experimental as well as clinical interest.

The nerve roots are the only site in the peripheral nervous system where efferent-motor and afferent-sensory nerve fibers are separated. This situation offers a multitude of possibilities for stringent experimental studies of the peripheral but also the central nervous system. A dorsal root lesion offers an uncompromised opportunity to assess after various manipulations spinal cord regeneration in a binary context. The clinical situation of plexus root avulsion from the spinal cord—usually after a trauma—is in fact a medullary lesion and can be considered in a cohort of patients as a proxy for a human spinal cord injury.

This chapter discusses the normal anatomy and describes surgical approaches as well as lesions and repair of the nerve plexus experimentally.

Key words

Nerve plexus Root avulsion Laminectomy Spinal cord Replantation Tissue glue 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Thomas Carlstedt
    • 1
  • Mårten Risling
    • 2
  1. 1.The Wolfson Centre for Age-Related DiseasesKing’s College LondonLondonUK
  2. 2.Experimental Traumatology, Department of NeuroscienceKarolinska InstitutetStockholmSweden

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