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Evolution of Peripheral Blood Stem Cell Transplantation

  • Anthony D. HoEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 2017)

Abstract

Blood-derived progenitors have become the predominant source of hematopoietic stem cells for clinical transplantation. The main advantages compared to the bone marrow are as follows: harvesting blood stem cells is less painful for the donor, utilizes much less resources such as operating theater time and general anesthesia, and, above all, is associated with significantly accelerated reconstitution. The latter has ultimately improved patient safety as a consequence of significantly shortened aplastic phase and hence reduced morbidity and mortality after transplantation. Basic and translational research efforts in the 1960s to the mid-1980s have made the first blood stem cell transplantation in Heidelberg in 1985 possible. Diverse groups around the world have contributed to incremental knowledge that culminated in the first successful attempts in blood stem cell transplantation. These efforts have spawned modern research into stem cell biology and the immune modulatory effects of allogeneic transplantations.

Key words

HSC mobilization HSC transplantation Engraftment 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine V (Hematology, Oncology, Rheumatology)Heidelberg UniversityHeidelbergGermany

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