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Enhanced Molecular Appreciation of Psychiatric Disorders Through High-Dimensionality Data Acquisition and Analytics

  • Jaana van Gastel
  • Jhana O. Hendrickx
  • Hanne Leysen
  • Bronwen Martin
  • Len Veenker
  • Sophie Beuning
  • Violette Coppens
  • Manuel MorrensEmail author
  • Stuart MaudsleyEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 2011)

Abstract

The initial diagnosis, molecular investigation, treatment, and posttreatment care of major psychiatric disorders (schizophrenia and bipolar depression) are all still significantly hindered by the current inability to define these disorders in an explicit molecular signaling manner. High-dimensionality data analytics, using large datastreams from transcriptomic, proteomic, or metabolomic investigations, will likely advance both the appreciation of the molecular nature of major psychiatric disorders and simultaneously enhance our ability to more efficiently diagnose and treat these debilitating conditions. High-dimensionality data analysis in psychiatric research has been heterogeneous in aims and methods and limited by insufficient sample sizes, poorly defined case definitions, methodological inhomogeneity, and confounding results. All of these issues combine to constrain the conclusions that can be extracted from them. Here, we discuss possibilities for overcoming methodological challenges through the implementation of transcriptomic, proteomic, or metabolomics signatures in psychiatric diagnosis and offer an outlook for future investigations. To fulfill the promise of intelligent high-dimensionality data-based differential diagnosis in mental disease diagnosis and treatment, future research will need large, well-defined cohorts in combination with state-of-the-art technologies.

Key words

High dimensionality Data acquisition Data analytics Transcriptomic Proteomic Metabolomic Psychiatric disorders 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jaana van Gastel
    • 1
    • 2
  • Jhana O. Hendrickx
    • 1
    • 2
  • Hanne Leysen
    • 1
    • 2
  • Bronwen Martin
    • 2
  • Len Veenker
    • 3
  • Sophie Beuning
    • 3
  • Violette Coppens
    • 3
  • Manuel Morrens
    • 3
    • 4
    Email author
  • Stuart Maudsley
    • 1
    • 2
    Email author
  1. 1.Receptor Biology Lab, Department of Biomedical ResearchUniversity of AntwerpAntwerpBelgium
  2. 2.Faculty of Pharmacy, Biomedical and Veterinary SciencesUniversity of AntwerpAntwerpBelgium
  3. 3.Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health SciencesUniversity of AntwerpAntwerpBelgium
  4. 4.University of Antwerp Department of Psychiatry, Campus DuffelDuffelBelgium

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