Surface Modification of Biomedically Essential Nanoparticles Employing Polymer Coating

  • Rahul Maheshwari
  • Nidhi Raval
  • Rakesh Kumar Tekade
Part of the Methods in Molecular Biology book series (MIMB, volume 2000)


Colloidal nanoparticles offering multiple biological applications carry tremendous potential to be developed as future medicines or nanomedicines. However, to decrease the particle agglomeration and enhance the stability of nanoparticles, functionalization could be of great interest. Functionalization is also capable of molding the delivery system for targeting and selective delivery of drugs and other biomolecules. In particular, the control over the size and the surface chemistry is crucial, since the successful applications in the prevention of diseases required biocompatibility at biological interfaces. Regardless of the advancements noted in nanotechnology-based nanoparticles, the development of nontoxic/biocompatible multi-functionalized nanoparticles is still a critical problem for researchers and requires urgent attention. In this chapter, an overview of nanoparticle functionalization with particular emphasis on its principle, needs, and formulation strategies has been discussed. Moreover, various applications of different surface-functionalized nanoparticles such as gold, silver, silicon, magnetic, liposomes, dendrimers, poly-lactic-co-glycolic acid, and solid lipid nanoparticles have also been presented.

Key words

Nanoparticles Surface-modified nanoparticles Gold nanoparticles Silver nanoparticles Functionalization methods Polymer coating Dendrimers Liposomes Solid lipid nanoparticles 



The authors would like to acknowledge Science and Engineering Research Board (Statutory Body Established Through an Act of Parliament: SERB Act 2008), Department of Science and Technology, Government of India, for the award of early carrier research grant (File Number: ECR/2016/001964) and DST-NPDF to Dr. Maheshwari (PDF/2016/003329) in Dr. Tekades’s lab. Authors would also like to thank NIPER Ahmedabad for providing research support for research on cancer and arthritis.


  1. 1.
    Maheshwari R, Tekade M, Sharma PA et al (2015) Nanocarriers assisted siRNA gene therapy for the management of cardiovascular disorders. Curr Pharm Des 21(30):4427–4440CrossRefGoogle Scholar
  2. 2.
    Sharma PA, Maheshwari R, Tekade M et al (2015) Nanomaterial based approaches for the diagnosis and therapy of cardiovascular diseases. Curr Pharm Des 21(30):4465–4478CrossRefGoogle Scholar
  3. 3.
    Lalu L, Tambe V, Pradhan D et al (2017) Novel nanosystems for the treatment of ocular inflammation: current paradigms and future research directions. J Control Release 268:19–39CrossRefGoogle Scholar
  4. 4.
    Maheshwari RG, Tekade RK, Sharma PA et al (2012) Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: a comparative assessment. Saudi Pharm J 20(2):161–170CrossRefGoogle Scholar
  5. 5.
    Tekade RK, Maheshwari R, Soni N et al (2017) Chapter 1—Nanotechnology for the development of nanomedicine A2—Mishra, Vijay. In: Kesharwani P, Amin MCIM, Iyer A (eds) Nanotechnology-based approaches for targeting and delivery of drugs and genes. Academic, New York, pp 3–61CrossRefGoogle Scholar
  6. 6.
    Tekade RK, Maheshwari R, Tekade M (2017) 4—Biopolymer-based nanocomposites for transdermal drug delivery. In: Jana S, Maiti S, Subrata BT (eds) Biopolymer-based composites. Woodhead Publishing, Cambridge, pp 81–106CrossRefGoogle Scholar
  7. 7.
    Tekade RK, Maheshwari R, Tekade M et al (2017) Chapter 8—Solid lipid nanoparticles for targeting and delivery of drugs and genes A2—Mishra, Vijay. In: Kesharwani P, Amin MCIM, Iyer A (eds) Nanotechnology-based approaches for targeting and delivery of drugs and genes. Academic, New York, pp 256–286CrossRefGoogle Scholar
  8. 8.
    Maheshwari RG, Thakur S, Singhal S et al (2015) Chitosan encrusted nonionic surfactant based vesicular formulation for topical administration of ofloxacin. Sci Adv Mater 7(6):1163–1176CrossRefGoogle Scholar
  9. 9.
    Tekade RK, Maheshwari R, Jain NK (2018) 9—Toxicity of nanostructured biomaterials A2—Narayan, Roger. Nanobiomaterials. Woodhead Publishing, p 231–256Google Scholar
  10. 10.
    Kumar Tekade R, Maheshwari RGS, Sharma PA et al (2015) siRNA therapy, challenges and underlying perspectives of dendrimer as delivery vector. Curr Pharm Des 21(31):4614–4636CrossRefGoogle Scholar
  11. 11.
    Maheshwari R, Tekade M, Gondaliya P et al (2017) Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers. Nanomedicine (Lond) 12(21):2653–2675CrossRefGoogle Scholar
  12. 12.
    Soni N, Soni N, Pandey H et al (2016) Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J Colloid Interface Sci 481:107–116CrossRefGoogle Scholar
  13. 13.
    Tekade RK, Maheshwari R, Soni N et al (2017) Chapter 12—carbon nanotubes in targeting and delivery of drugs A2—Mishra, Vijay. In: Kesharwani P, Amin MCIM, Iyer A (eds) Nanotechnology-based approaches for targeting and delivery of drugs and genes. Academic, New York, pp 389–426CrossRefGoogle Scholar
  14. 14.
    Yan J, Li Z, Wang L et al (2008) Preparation and characterization of BaLiF3:Er3+ nanoparticles by the hydrothermal microemulsion synthesized method. J Rare Earths 26(1):48–50CrossRefGoogle Scholar
  15. 15.
    Fang L, Wang F, Chen Z et al (2017) Flower-like MoS2 decorated with Cu2O nanoparticles for non-enzymatic amperometric sensing of glucose. Talanta 167:593–599CrossRefGoogle Scholar
  16. 16.
    Wang J, Wang M, Zheng M et al (2015) Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery. Colloids Surf B: Biointerfaces 129:63–70CrossRefGoogle Scholar
  17. 17.
    Bennet D, Kim S (2014) Polymer nanoparticles for smart drug delivery. In: Sezer AD (ed) Application of nanotechnology in drug delivery. InTech, RijekaGoogle Scholar
  18. 18.
    Maisel K, Ensign L, Reddy M et al (2015) Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. J Control Release 197:48–57CrossRefGoogle Scholar
  19. 19.
    Nasir I, Lundqvist M, Cabaleiro-Lago C (2015) Size and surface chemistry of nanoparticles lead to a variant behavior in the unfolding dynamics of human carbonic anhydrase. Nanoscale 7(41):17504–17515CrossRefGoogle Scholar
  20. 20.
    Podgórna K, Jankowska K, Szczepanowicz K (2017) Polysaccharide gel nanoparticles modified by the Layer-by-Layer technique for biomedical applications. Colloids Surf A Physicochem Eng Asp 519:192–198CrossRefGoogle Scholar
  21. 21.
    Nirmala JG, Akila S, Narendhirakannan R et al (2017) Vitis vinifera peel polyphenols stabilized gold nanoparticles induce cytotoxicity and apoptotic cell death in A431 skin cancer cell lines. Adv Powder Technol 28(4):1170–1184CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Rahul Maheshwari
    • 1
  • Nidhi Raval
    • 1
  • Rakesh Kumar Tekade
    • 1
  1. 1.National Institute of Pharmaceutical Education and Research (NIPER)—AhmedabadGandhinagarIndia

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