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Surface Modification of Biomedically Essential Nanoparticles Employing Polymer Coating

  • Rahul Maheshwari
  • Nidhi Raval
  • Rakesh Kumar Tekade
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 2000)

Abstract

Colloidal nanoparticles offering multiple biological applications carry tremendous potential to be developed as future medicines or nanomedicines. However, to decrease the particle agglomeration and enhance the stability of nanoparticles, functionalization could be of great interest. Functionalization is also capable of molding the delivery system for targeting and selective delivery of drugs and other biomolecules. In particular, the control over the size and the surface chemistry is crucial, since the successful applications in the prevention of diseases required biocompatibility at biological interfaces. Regardless of the advancements noted in nanotechnology-based nanoparticles, the development of nontoxic/biocompatible multi-functionalized nanoparticles is still a critical problem for researchers and requires urgent attention. In this chapter, an overview of nanoparticle functionalization with particular emphasis on its principle, needs, and formulation strategies has been discussed. Moreover, various applications of different surface-functionalized nanoparticles such as gold, silver, silicon, magnetic, liposomes, dendrimers, poly-lactic-co-glycolic acid, and solid lipid nanoparticles have also been presented.

Key words

Nanoparticles Surface-modified nanoparticles Gold nanoparticles Silver nanoparticles Functionalization methods Polymer coating Dendrimers Liposomes Solid lipid nanoparticles 

Notes

Acknowledgments

The authors would like to acknowledge Science and Engineering Research Board (Statutory Body Established Through an Act of Parliament: SERB Act 2008), Department of Science and Technology, Government of India, for the award of early carrier research grant (File Number: ECR/2016/001964) and DST-NPDF to Dr. Maheshwari (PDF/2016/003329) in Dr. Tekades’s lab. Authors would also like to thank NIPER Ahmedabad for providing research support for research on cancer and arthritis.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Rahul Maheshwari
    • 1
  • Nidhi Raval
    • 1
  • Rakesh Kumar Tekade
    • 1
  1. 1.National Institute of Pharmaceutical Education and Research (NIPER)—AhmedabadGandhinagarIndia

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