Enantioseparations by Gas Chromatography Using Porous Organic Cages as Stationary Phase
The resolution of chiral compounds into optically pure enantiomers is very important in various fields, such as pharmaceutical, chemical, agricultural, and food industries. Chiral gas chromatography (GC) is one of the efficient methods for enantioseparations of volatile compounds. In recent years, porous materials as stationary phases for chromatographic separations have achieved increasing attention. Porous organic cages (POCs) represent an emerging class of porous materials, which are assembled by discrete organic molecules with shape-persistent and permanent cavities through weak intermolecular forces. This chapter describes several chiral POCs as chiral stationary phases for GC enantioseparations of racemic compounds.
Key wordsEnantioseparation Chiral stationary phase Gas chromatography Porous material Porous organic cage
This work was supported by the National Natural Science Foundation (Nos. 21765025, 21705142, 21675141, 21365024) of China and Applied Basic Research Foundation of Yunnan Province (No. 2017FB013).
- 3.Schurig V (2011) Separation of enantiomers by gas chromatography on chiral stationary phases, Chapter 9. In: Ahuja S (ed) Chiral separation methods. Wiley, Hoboken, pp 251–297Google Scholar
- 23.Chen L, Reiss PS, Chong SY, Holden D, Jelfs KE, Hasell T, Little MA, Kewley A, Briggs ME, Stephenson A, Thomas KM, Armstrong JA, Bell J, Busto J, Noel R, Liu J, Strachan DM, Thallapally PK, Cooper AI (2014) Separation of rare gases and chiral molecules by selective binding in porous organic cages. Nat Mater 13:954–960CrossRefGoogle Scholar