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Combing the Hairball: Improving Visualization of miRNA–Target Interaction Networks

  • Francesco RussoEmail author
  • Jessica Xin Hu
  • Jose Alejandro Romero Herrera
  • Søren Brunak
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1970)

Abstract

The visualization of regulatory networks is becoming increasingly important in order to understand molecular mechanisms and diseases. MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) responsible of the post-transcriptional regulation of messenger RNAs (mRNAs) and other ncRNAs. MiRNAs are involved in numerous biological processes including development, cell proliferation, and apoptosis. They are also key molecules in major complex diseases such as cancer and cardiovascular diseases. A single miRNA can regulate many targets, making the analysis and visualization of these complex networks challenging. Here, we present standard and advanced visualization approaches to represent networks with a special focus on miRNA–target interactions.

Key words

MicroRNAs Noncoding RNAs Visualization Regulatory networks Target prediction 

Notes

Acknowledgments

The authors would like to acknowledge funding from the Novo Nordisk Foundation (grant agreement NNF14CC0001).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Francesco Russo
    • 1
    Email author
  • Jessica Xin Hu
    • 1
  • Jose Alejandro Romero Herrera
    • 1
  • Søren Brunak
    • 1
  1. 1.Novo Nordisk Foundation Center for Protein Research, Translational Disease Systems Biology, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

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