Computational Methods to Investigate the Impact of miRNAs on Pathways

  • Salvatore Alaimo
  • Giovanni Micale
  • Alessandro La Ferlita
  • Alfredo Ferro
  • Alfredo PulvirentiEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1970)


Pathway analysis is a wide class of methods allowing to determine the alteration of functional processes in complex diseases. However, biological pathways are still partial, and knowledge coming from posttranscriptional regulators has started to be considered in a systematic way only recently. Here we will give a global and updated view of the main pathway and subpathway analysis methodologies, focusing on the improvements obtained through the recent introduction of microRNAs as regulatory elements in these frameworks.

Key words

Computational pathway analysis Subpathways mining MicroRNAs Precision medicine Next-generation sequencing High-throughput sequencing 



This work has been done within the research project “Marcatori molecolari e clinico-strumentali precoci, nelle patologie metaboliche e cronico-degenerative,” funded by the Department of Clinical and Experimental of University of Catania.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Salvatore Alaimo
    • 1
  • Giovanni Micale
    • 1
  • Alessandro La Ferlita
    • 2
  • Alfredo Ferro
    • 1
  • Alfredo Pulvirenti
    • 1
    Email author
  1. 1.Department of Clinical and Experimental MedicineUniversity of CataniaCataniaItaly
  2. 2.Department of Physics and AstronomyUniversity of CataniaCataniaItaly

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