IVIS Spectrum CT to Image the Progression of Pneumococcal Infections In Vivo

  • Adam Sierakowiak
  • Birgitta Henriques-Normark
  • Federico IovinoEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1968)


Imaging through the IVIS Spectrum CT system does not provide the resolution at cellular level like the high-resolution or super-resolution microscopy. Rather, it detects bacterial infections in specific anatomical compartments/organs of the animals. The IVIS Spectrum imaging system is a unique imaging technology that allows for real-time monitoring of disease progression in living animals through the use of either bioluminescent or fluorescent probes.

Key words

Real-time In vivo imaging IVIS Bioluminescence Fluorescence 3D modeling 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Adam Sierakowiak
    • 1
  • Birgitta Henriques-Normark
    • 2
    • 3
    • 4
  • Federico Iovino
    • 2
    • 3
    Email author
  1. 1.Department of Oncology-PathologyKarolinska Institutet and Karolinska University HospitalStockholmSweden
  2. 2.Department of Microbiology, Tumor and Cell BiologyKarolinska Institutet, BioclinicumStockholmSweden
  3. 3.Department of Clinical MicrobiologyKarolinska University HospitalStockholmSweden
  4. 4.Singapore Centre on Environmental Life Sciences Engineering (SCELSE), and Lee Kong Chian School of Medicine (LCK)Nanyang Technological University (NTU)SingaporeSingapore

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