Astrocytes pp 265-276 | Cite as

A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque

  • Kevin B. Chiu
  • Kim M. Lee
  • Katelyn N. Robillard
  • Andrew G. MacLeanEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1938)


With a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. Using the unique archive at the Tulane National Primate Research Center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. This method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner.

Key words

Astrocyte Microglia Neurodegeneration Aging Neuroinflammation Eugeric 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kevin B. Chiu
    • 1
    • 2
  • Kim M. Lee
    • 1
    • 3
    • 4
  • Katelyn N. Robillard
    • 1
    • 5
  • Andrew G. MacLean
    • 1
    • 4
    • 6
    • 7
    Email author
  1. 1.Tulane National Primate Research CenterCovingtonUSA
  2. 2.Department of Biomedical EngineeringTulane UniversityNew OrleansUSA
  3. 3.Vanderbilt Hospital NashvilleNashvilleUSA
  4. 4.Tulane Program in Biomedical SciencesTulane University School of MedicineNew OrleansUSA
  5. 5.Neuroscience Center of ExcellenceLouisiana State University Health Sciences CenterNew OrleansUSA
  6. 6.Tulane Brain InstituteTulane UniversityNew OrleansUSA
  7. 7.Department of Microbiology and ImmunologyTulane University School of MedicineNew OrleansUSA

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