Object Burying Test for Assessment of Obsessive Compulsive Behaviors in Mice

  • Ann-Katrin Kraeuter
  • Paul C. Guest
  • Zoltán SarnyaiEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1916)


Obsessive-compulsive disorder (OCD) can occur in several psychiatric illnesses such as autism spectrum disorders (ASD) and it is more prevalent in children. This condition is characterized by repeated and apparently meaningless behaviors such as frequent hand washing, counting, tapping, and rocking. This can disrupt normal socialization and in some cases lead to self-harm. Therefore there is interest in developing more effective therapies for individuals suffering from these conditions. This chapter describes how to conduct the mouse marble burying test as a sensitive measure of compulsive behaviors.

Key words

Behavior Obsessive-compulsive disorder Autism spectrum disorder Mouse Marble burying 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ann-Katrin Kraeuter
    • 1
    • 2
  • Paul C. Guest
    • 3
  • Zoltán Sarnyai
    • 1
    • 2
    Email author
  1. 1.Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and MedicineJames Cook UniversityTownsvilleAustralia
  2. 2.Discipline of Biomedicine, College of Public Health, Medicine and Veterinary SciencesJames Cook UniversityTownsvilleAustralia
  3. 3.Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of BiologyUniversity of Campinas (UNICAMP)CampinasBrazil

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