Assaying Reproductive Capacity in Female Rodents
It is an important part of many rodent studies to assess reproductive capacity in the female. Animal models that involve exposure to organic compounds, teratogenicity studies, or exposure to suboptimal environments during early development often result in deficits in female fertility. In addition to longitudinal physiology assays of fecundity, there are several molecular biology approaches to assessing female reproductive potential that can be performed to provide a “snapshot” of fertility potential at a single time-point. Here we describe some of the most useful ways to assess female reproductive capacity in rodents.
Key wordsOvary Female Reproductive system Estropause Follicle
The authors are members of the University of Cambridge MRC Metabolic Disease Unit and are funded by the UK Medical Research Council MC UU12012/04). CA is funded by a grant from the Addenbrooke’s Charitable Trust (ACT) and by the NIHR Cambridge Comprehensive Biomedical Research Centre.
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