Procurement and Storage of Surgical Biospecimens
A biobank is an important nexus between clinical and research aspects of pathology. The collection and storage of high quality surgical samples is essential for diagnosis post-surgery, and can also be used to create vaccines, identify therapeutic targets or establish eligibility of cancer patients in a clinical trial. Therefore, personnel handling surgical tissues should follow standard operating procedures (SOP) to maximize efficiency and preserve tissue quality. This chapter is intended to familiarize novice biobank personnel with the issues associated with different steps of surgical tissue collection including patient consent, sample collection, tissue storage, quality control, and distribution.
Key wordsSurgical Tissue Biospecimen Biobank Biorepository Procurement Nucleic acids Pathology
This work was supported in part by NIH:NCI P50-CA211015, NIH:NIMH U24 MH100929, the Art of the Brain Foundation, and the Henry E. Singleton Brain Cancer Research Program.
- 1.Tuck MK, Chan DW, Chia D et al (2009) Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. J Proteome Res 8(1):113–117. https://doi.org/10.1021/pr800545qCrossRefPubMedPubMedCentralGoogle Scholar
- 5.Hakimian R, Taube S, Bledsoe M, et al (2004) National Cancer Institute Cancer Diagnosis Program: 50—state survey of laws regarding the collection, storage, and use of human tissue specimens and associated data for research. National Institutes of Health, Bethesda, MD, NIH Publication No: 05-5628Google Scholar
- 6.Yong WH, Dry SM, Shabikhani M (2014) A practical approach to clinical and research biobanking. In: Day CE (ed) Histopathology, methods and protocols. Humana Press, New YorkGoogle Scholar