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Biobanking pp 115-124 | Cite as

Biobanking of Urine Samples

  • Neda A. MoatamedEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1897)

Abstract

Urine is a major repository of biometabolites, some proteins, and DNA. Within the past few decades, it has become increasingly apparent that certain infectious, neoplastic, and congenital diseases can be investigated using urine samples for diagnostic and prognostic purposes. In this chapter, a number of pertinent urine analytes and methods of banking urine samples for future analyses are discussed.

Key words

Urine Genitourinary Banking Proteomics Proteins Nucleic acids DNA Biosample Biobank Biorepository 

References

  1. 1.
    Kemper FH (1993) Human organ specimen banking—15 years of experience. Sci Total Environ 139–140:13–25CrossRefGoogle Scholar
  2. 2.
    Jackson C, Best N, Elliott P (2008) UK Biobank Pilot Study: stability of haematological and clinical chemistry analytes. Int J Epidemiol 37(Suppl 1):i16–i22CrossRefGoogle Scholar
  3. 3.
    Van Noord PA (2003) Banking of urine sediments as DNA source in epidemiologic studies. Epidemiology 14:254 author reply 254–255CrossRefGoogle Scholar
  4. 4.
    Echeverry G, Hortin GL, Rai AJ (2010) Introduction to urinalysis: historical perspectives and clinical application. In: Rai AJ (ed) The urinary proteome methods and protocols, 1st edn. Springer, New York, pp 1–12Google Scholar
  5. 5.
    Hussong JW, Kjeldsberg CR (eds) (2014) Kjeldsberg’s body fluid analysis. American Society for Clinical Pathology, ChicagoGoogle Scholar
  6. 6.
    Thongboonkerd V, Saetun P (2007) Bacterial overgrowth affects urinary proteome analysis: recommendation for centrifugation, temperature, duration, and the use of preservatives during sample collection. J Proteome Res 6:4173–4181CrossRefGoogle Scholar
  7. 7.
    Quek SI, Wong OM, Chen A et al (2015) Processing of voided urine for prostate cancer RNA biomarker analysis. Prostate 75:1886–1895CrossRefGoogle Scholar
  8. 8.
    Saetun P, Semangoen T, Thongboonkerd V (2009) Characterizations of urinary sediments precipitated after freezing and their effects on urinary protein and chemical analyses. Am J Physiol Renal Physiol 296:F1346–F1354CrossRefGoogle Scholar
  9. 9.
    Fiedler GM, Ceglarek U, Leichtle A et al (2010) Standardized preprocessing of urine for proteome analysis. In: Rai AJ (ed) The urinary proteome methods and protocols, 1st edn. Springer, New York, pp 47–63CrossRefGoogle Scholar
  10. 10.
    Jackson DH, Banks RE (2010) Banking of clinical samples for proteomic biomarker studies: a consideration of logistical issues with a focus on pre-analytical variation. Proteomics Clin Appl 4:250–270CrossRefGoogle Scholar
  11. 11.
    Cairns P (2004) Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Ann N Y Acad Sci 1022:40–43CrossRefGoogle Scholar
  12. 12.
    Mehta TK, Hoque MO, Ugarte R et al (2006) Quantitative detection of promoter hypermethylation as a biomarker of acute kidney injury during transplantation. Transplant Proc 38:3420–3426CrossRefGoogle Scholar
  13. 13.
    Roest M, van der Schouw YT, de Valk B et al (1999) Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women. Circulation 100:1268–1273CrossRefGoogle Scholar
  14. 14.
    Van Noord PA (1985) Epidemiological aspects of data banks and biological banks. Tijdschr Diergeneeskd 110:703–715PubMedGoogle Scholar
  15. 15.
    Murdoch DR, Walford EJ, Jennings LC et al (1996) Use of the polymerase chain reaction to detect Legionella DNA in urine and serum samples from patients with pneumonia. Clin Infect Dis 23:475–480CrossRefGoogle Scholar
  16. 16.
    Cannas A, Kalunga G, Green C et al (2009) Implications of storing urinary DNA from different populations for molecular analyses. PLoS One 4:e6985CrossRefGoogle Scholar
  17. 17.
    Chapin KC (2006) Molecular tests for detection of the sexually-transmitted pathogens Neisseria gonorrhoeae and Chlamydia trachomatis. Med Health R I 89:202–204PubMedGoogle Scholar
  18. 18.
    Fisa R, Riera C, Lopez-Chejade P et al (2008) Leishmania infantum DNA detection in urine from patients with visceral leishmaniasis and after treatment control. Am J Trop Med Hyg 78:741–744CrossRefGoogle Scholar
  19. 19.
    Mharakurwa S, Simoloka C, Thuma PE et al (2006) PCR detection of Plasmodium falciparum in human urine and saliva samples. Malar J 5:103CrossRefGoogle Scholar
  20. 20.
    Cannas A, Goletti D, Girardi E et al (2008) Mycobacterium tuberculosis DNA detection in soluble fraction of urine from pulmonary tuberculosis patients. Int J Tuberc Lung Dis 12:146–151PubMedGoogle Scholar
  21. 21.
    Elliott P, Peakman TC, Biobank UK (2008) The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int J Epidemiol 37:234–244CrossRefGoogle Scholar
  22. 22.
    Riegman PH, Morente MM, Betsou F et al (2008) Biobanking for better healthcare. Mol Oncol 2:213–222CrossRefGoogle Scholar
  23. 23.
    Povey S, Al Aqeel AI, Cambon-Thomsen A et al (2010) Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs). Hum Mutat 31:1179–1184CrossRefGoogle Scholar
  24. 24.
    Holland NT, Smith MT, Eskenazi B et al (2003) Biological sample collection and processing for molecular epidemiological studies. Mutat Res 543:217–234CrossRefGoogle Scholar
  25. 25.
    Cambon-Thomsen A (2004) The social and ethical issues of post-genomic human biobanks. Nat Rev Genet 5:866–873CrossRefGoogle Scholar
  26. 26.
    Protections OfHR (2014) International compilation of human research standards. Services USDoHaH: http://www.hhs.gov/ohrp/international/intlcompilation/2014intlcomp.pdf.pdf
  27. 27.
    Van Veen EB, Riegman PH, Dinjens WN et al (2006) TuBaFrost 3: regulatory and ethical issues on the exchange of residual tissue for research across Europe. Eur J Cancer 42:2914–2923CrossRefGoogle Scholar
  28. 28.
    Chabannon C, Doran P, Hofman P et al (2012) Annual conferences of the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB): overview of 2011 and preview of 2012. Biopreserv Biobank 10:407–415CrossRefGoogle Scholar
  29. 29.
    Harris JR, Burton P, Knoppers BM et al (2012) Toward a roadmap in global biobanking for health. Eur J Hum Genet 20:1105–1111CrossRefGoogle Scholar
  30. 30.
    Mischak H, Kolch W, Aivaliotis M et al (2010) Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clin Appl 4:464–478CrossRefGoogle Scholar
  31. 31.
    Ercan M, Akbulut ED, Abusoglu S et al (2015) Stability of urine specimens stored with and without preservatives at room temperature and on ice prior to urinalysis. Clin Biochem 48:919–922CrossRefGoogle Scholar
  32. 32.
    Nabi G, N’Dow J, Hasan TS et al (2005) Proteomic analysis of urine in patients with intestinal segments transposed into the urinary tract. Proteomics 5:1729–1733CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory Medicine, David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesUSA

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