Sustainability in Biobanking

  • Maram Abdaljaleel
  • Elyse J. Singer
  • William H. YongEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1897)


Biobanks are storage places for biospecimens that can be used for current and future scientific research. Biospecimens are exceptional sources of biological data that can be potentially translated from molecular and genetic information to clinically relevant treatment modalities. Examples of such biospecimens include, but are not limited to, blood, skin, hair, saliva, stem cells, DNA, and RNA. The volume of biospecimens worldwide continues to grow at an extraordinary rate posing a challenge for biobanks to manage this growth. Due to the vital role of biobanks in research, an understanding of biobanking sustainability is important. Simply starting to collect biospecimens without strategic planning and cost analysis can lead to failure. Components vital to sustainability include fostering public support, cost-effective banking, funding development, standardized protocols, and interoperability.

Key words

Biobank Biospecimens Sustainability Interoperability Standards Accreditation 



This work was supported in part by NIH:NCI P50-CA211015, NIH:NIMH U24 MH100929, the Art of the Brain Foundation, and the Henry E. Singleton Brain Cancer Research Program.


  1. 1.
    UN projects world population to reach 8.5 billion by 2030, driven by growth in developing countries | UN News. (n.d.).
  2. 2.
    McDonald SA et al (2012) Fee-for-service as a business model of growing importance: the academic biobank experience. Biopreserv Biobanking 10(5):421–425. Scholar
  3. 3.
    Chan TW. The closure of the national bio-bank in Singapore. Accessed 21 Oct 2015
  4. 4.
    Watson PH et al (2014) A framework for biobank sustainability. Biopreserv Biobanking 12(1):60–68. Scholar
  5. 5.
    Hansson MG (2011) The need to downregulate: a minimal ethical framework for biobank research. Methods Mol Biol 675:39–59. Scholar
  6. 6.
    Helgesson G et al (2007) Ethical framework for previously collected biobank samples. Nat Biotechnol 25(9):973–976. Scholar
  7. 7.
    Rothstein MA (2005) Expanding the ethical analysis of biobanks. J Law Med Ethics 33(1):89–101CrossRefGoogle Scholar
  8. 8.
    Hawkins AK (2010) Biobanks: importance, implications and opportunities for genetic counselors. J Genet Couns 19(5):423–429. Scholar
  9. 9.
    Joly Y, Knoppers BM (2006) Pharmacogenomic data sample collection and storage: ethical issues and policy approaches. Pharmacogenomics 7(2):219–226. Scholar
  10. 10.
    Kiehntopf M, Krawczak M (2011) Biobanking and international interoperability: samples. Hum Genet 130(3):369–376. Scholar
  11. 11.
    Hawkins AK, O’Doherty KC (2011) ‘Who owns your poop?’: insights regarding the intersection of human microbiome research and the ELSI aspects of biobanking and related studies. BMC Med Genet 4:72. Scholar
  12. 12.
    Welcome to the biorepositories and biospecimen research branch (BBRB). Accessed 19 Oct 2015
  13. 13.
    ISBER. Accessed 19 Oct 2015
  14. 14.
  15. 15.
    Supporting Interoperability – Terminology, Subsets and Other Resources from NLM. Accessed 1 Oct 2018
  16. 16.
    Glossary, FAQs, help files, pocket cards. Accessed 21 Oct 2015

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Maram Abdaljaleel
    • 1
  • Elyse J. Singer
    • 2
  • William H. Yong
    • 1
    • 3
    • 4
    Email author
  1. 1.Division of Neuropathology, Department of Pathology and Laboratory MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of NeurologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Brain Tumor Translational ResourceDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Jonsson Comprehensive Cancer CenterDavid Geffen School of Medicine at UCLALos AngelesUSA

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