Tumor-Derived Microparticles to Monitor Colorectal Cancer Evolution
Colorectal cancer is the most common gastrointestinal cancer and the second-most common cause of cancer-related death worldwide. Microparticles are small vesicles known to be implicated in tumor growth, the development of metastases, and cancer-associated procoagulant activity. We have reported a specific hallmark of microparticles in colorectal and pancreatic cancers, the so-called “microparticulosome.” We have also reported on variations in the microparticulosome in the case of the occurrence of a thromboembolic event. Here, we describe our flow cytometry-based methods for identifying and characterizing tumor-derived microparticles and thereby monitoring colorectal cancer evolution.
Key wordsMicroparticle Tumor-derived microvesicle Colorectal cancer Tissue factor Fibrin
- 12.Mege D, Crescence L, Ouaissi M, Sielezneff I, Guieu R, Dignat-George F, Dubois C, Panicot-Dubois L (2017) Fibrin-bearing microparticles: marker of thrombo-embolic events in pancreatic and colorectal cancers. Oncotarget 8(57):97394–97406Google Scholar