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Insights of Acute Lymphoblastic Leukemia with Development of Genomic Investigation

  • Heng Xu
  • Yang Shu
Part of the Methods in Molecular Biology book series (MIMB, volume 1754)

Abstract

Treatment outcomes for acute lymphoblastic leukemia (ALL), especially pediatric ALL, have greatly improved due to the risk-adapted therapy. Combination of drug development, clinical practice, as well as basic genetic researches has brought the survival rate of ALL from less than 10% to more than 90% today, not only increasing the treatment efficacy but also limiting adverse drug reactions (ADRs). In this review, we summarized the landscape identification of ALL genetic alterations, which provided the opportunity to increase the survival rate and especially minimize the relapse risk of ALL, and highlighted the importance of the development of new technologies of genomic investigation for translational medicine.

Key words

Acute lymphoblastic leukemia Next-generation sequencing Microarray Single nucleotide polymorphism Mutation Drug efficacy Adverse drug reactions Translational medicine Genomic landscape Bioinformatics Big data 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Precision Medicine Center, State Key Laboratory of Biotherapy, Precision Medicine Key Laboratory of Sichuan Province, West China HospitalSichuan UniversityChengduChina

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