Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci
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Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually evolving through technical advancements and the development of new bioinformatic tools for analyzing genomic data; however, the basic principles and processes for defining and processing high-quality genome sequence information remain unchanged. Here, we introduce some considerations and describe some commonly used bioinformatic steps for processing raw genome sequence data to generate genome assemblies through to understanding basic population genomics.
Key wordsPopulation genomics Comparative genomics Genome sequencing Next-generation sequencing Reference genome Group A Streptococcus Streptococcus pyogenes
This work was supported by NHMRC project grants (#1130455, #1165876 and #1098319). S.Y.C.T. is an Australian National Health and Medical Research Council (NHMRC) Career Development Fellow (#1145033). M.R.D is an University of Melbourne C.R. Roper Fellow.
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