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Large Animal Models of Diabetes

  • Barbara LudwigEmail author
  • Eckhard Wolf
  • Uwe Schönmann
  • Stefan Ludwig
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Part of the Methods in Molecular Biology book series (MIMB, volume 2128)

Abstract

Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.

Key words

Diabetes model Diabetes induction Pig model Primate model Streptozotocin Pancreatectomy 

Abbreviations

BG

Blood glucose

BW

Body weight

im

Intramuscular

iv

Intravenous

NHP

Nonhuman primate

sc

Subcutaneous

STZ

Streptozotocin

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Barbara Ludwig
    • 1
    • 2
    • 3
    • 4
    Email author
  • Eckhard Wolf
    • 5
  • Uwe Schönmann
    • 6
  • Stefan Ludwig
    • 7
  1. 1.Department of Medicine IIIUniversity Hospital Carl Gustav CarusDresdenGermany
  2. 2.Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus and Faculty of Medicine of the TU DresdenDresdenGermany
  3. 3.DFG-Center for Regenerative Therapies Dresden, Technische Universität DresdenDresdenGermany
  4. 4.Department of Endocrinology and DiabetologyUniversity Hospital ZurichZurichSwitzerland
  5. 5.Department of Molecular Animal Breeding and BiotechnologyLudwig Maximilian UniversityMunichGermany
  6. 6.German Primate CenterLeibniz-Institute for Primate ResearchGöttingenGermany
  7. 7.Department of Visceral, Thoracic and Vascular SurgeryUniversity Hospital Carl Gustav CarusDresdenGermany

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