Macroscopic Examination of Surgical Specimen of Esophageal Squamous Cell Carcinoma
- 43 Downloads
Macroscopic examination of the surgical specimen of esophageal squamous cell carcinoma by pathologist is important for quality clinical management, research, as well as education purposes. The process includes dissection of the specimen, identification of the lesion, measurements, and taking appropriate samples for histopathological examination. The basic principle of the examination is to study the characteristics and extent of the cancer. In addition, examination of proximal resection margin and circumferential resection margin are important in the cancer. A standardized approach for macroscopic examination by professionals is needed for accurate diagnosis and to optimize the use of the surgical specimen with esophageal squamous cell carcinoma.
Key wordsEsophageal squamous cell carcinoma Macroscopic Cut up Resection
- 3.Wong ML, Tao Q, Fu L, Wong KY, Qiu GH, Law FB, Tin PC, Cheung WL, Lee PY, Tang JC, Tsao GS, Lam KY, Law S, Wong J, Srivastava G (2006) Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma. Int J Oncol 28:767–773PubMedGoogle Scholar
- 4.Hu YC, Lam KY, Law S, Wong J, Srivastava G (2001) Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC. Clin Cancer Res 7:3519–3525PubMedGoogle Scholar
- 8.Hu YC, Lam KY, Law SY, Wan TS, Ma ES, Kwong YL, Chan LC, Wong J, Srivastava G (2002) Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines. Cancer Genet Cytogenet 135:120–127CrossRefGoogle Scholar
- 14.Kumarasinghe MP, Brown IS, Charlton A, De Boer B, Eckstein R, Epari K, Gill A. Lam A, Lauwers G, Raftopoulos S, Price T (2013) Tumours of the oesophagus and gastro-oesophageal junction structured reported protocol, 1st edition, Published on web by Royal College of Pathologists of Australasia. http://www.rcpa.edu.au//Library/Practising-Pathology/Structured-Pathology-Reporting-of-Cancer/Cancer-Protocols