Cell Tracking pp 127-139 | Cite as

Antibody-Targeted Magnetic Nanoparticles to Track Immune Cells In Vivo

  • Kayla EschlimanEmail author
  • Stefan H. Bossmann
Part of the Methods in Molecular Biology book series (MIMB, volume 2126)


Brain tumors can prove difficult to diagnose and successfully treat. Gliomas, and in particular glioblastomas, are the most common type of primary brain tumor. The most difficult part about treating these tumors is the fact that they are able to migrate through the extracellular space inside the brain. Recurrence is also highly possible due to their invasive nature, leading to the destruction of nearby tissues. The migratory nature of these tumors makes imaging difficult. To combat this, antibodies can be conjugated to the surface of nanoparticles such as superparamagnetic iron oxide (SPIO) nanoparticles to help target the immune cells. This creates a unique bimodal system that is able to detect the brain cancer cells and assist tumor surgery in conjunction with magnetic resonance imaging (MRI).

Key words

Nanoparticles Immunotherapy Iron Oxide Cell Tracking Antibodies 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Chemistry and Johnson Cancer Research CenterKansas State UniversityManhattanUSA

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