Analysis of Hematopoietic Niche in the Mouse Embryo
The development, differentiation, and maturation of hematopoietic cells are regulated by the intrinsic and extrinsic regulation. Intrinsic activity is affected by cell autonomous gene expression and extrinsic factors originate from the so-called niche surrounding the hematopoietic cells. It remains unclear why the hematopoietic sites are shifted during embryogenesis. Flow cytometry and immunohistochemistry enable us to study embryonic regulation of hematopoietic niche in the mouse embryo.
KeywordsEmbryo Hematopoietic Mouse Niche
We thank the Ministry of Education, Culture, Sports, Science and Technology; The Ministry of Health, Labor and Welfare; and the Japan Society for the Promotion of Science for grant support.