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Acute Clip Impact-Compression Model

  • Protocol
Animal Models of Acute Neurological Injuries

Part of the book series: Springer Protocols Handbooks ((SPH))

In human spinal cord injury, the most common mechanism is the combination of acute impact and continuing compression. To simulate combined impact-compression, we developed in the 1970s the acute clip impact-compression model, one of the first nontransection models in the rodent. Subsequently, we characterized the relationships between clip strength, duration of compression, and neurological recovery, and established dose-response relationships between the forces of clip compression injury, axon-evoked potentials, spinal cord blood flow, neurological function, axon counts, and retrograde labeling of supraspinal neurons with axonal tracers. Clip injury is useful for in vitro and in vivo SCI studies in rats and mice for cervical, thoracic, and lumbar injuries, and is consistent, reliable, and relatively inexpensive.

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Author information

Authors and Affiliations

  1. Toronto Western Hospital, Toronto, ON, Canada

    Charles H. Tator & Peter Poon

Authors
  1. Charles H. Tator
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  2. Peter Poon
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen M.D.

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu M.D., Ph.D.

  3. Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Xiao-Ming Xu M.D., Ph.D.

  4. Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, CA, USA

    John H. Zhang M.D., Ph.D.

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© 2009 Humana Press, a part of Springer Science + Business Media, LLC

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Tator, C.H., Poon, P. (2009). Acute Clip Impact-Compression Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_38

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  • DOI: https://doi.org/10.1007/978-1-60327-185-1_38

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-184-4

  • Online ISBN: 978-1-60327-185-1

  • eBook Packages: Springer Protocols

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