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Double Blood-Injection Cerebral Vasospasm Canine Model

  • Protocol
Animal Models of Acute Neurological Injuries

Part of the book series: Springer Protocols Handbooks ((SPH))

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The details of double blood-injection vasospasm canine model are described. In the viewpoints of severity of arterial constriction, time course, and histological changes of cerebral artery exposed subarahcnoid blood clot, it can be a most suitable experimental animal model for the investigation of pathophysilogy of cerebral vasospasm following subarachnoid hemorrhage.

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References

  1. Echlin FA. Spasm of basilar and vertebral arteries caused by experimental subarachnoid hemorrhage. J Neurosurg 1965; 23: 1–11.

    PubMed  CAS  Google Scholar 

  2. Allcock JM. Arterial spasm in subarachnoid haemorrhage. A clinical and experimental study. Acta Radiol 1966; 5: 73–83.

    CAS  Google Scholar 

  3. Browley BW, Strandness DE, Kelly WA. The biphasic response of cerebral vasos-pasm in experimental subarachnoid hemorrhage. J Neurosurg 1968; 28: 1–8.

    Google Scholar 

  4. Chow RWB, Newton TH, Smith MC. Cerebral vasospasm induced by subarachnoid blood and serotonin. An angiographic study. Invest Radiol 1968; 3: 402–407.

    Article  PubMed  CAS  Google Scholar 

  5. Kapp J, Mahaley MS Jr, Odom GL. Cerebral arterial spasm. Part I: Evaluation of experimental variables affecting the diameter of the exposed basilar artery. J Neurosurg 1968; 29: 331–338.

    PubMed  CAS  Google Scholar 

  6. Landau B, Ransohoff J. Prolonged cerebral vasospasm in experimental subarach-noid hemorrhage. Neurology (Minneap) 1968; 18: 1056–1065.

    CAS  Google Scholar 

  7. Simeone FA, Ryan KG, Cotter JR. Prolonged experimental cerebral vasospasm. J Neurosurg 1968; 29: 357–366.

    PubMed  CAS  Google Scholar 

  8. Arutiunov AI, Baron MA, Majorova NA. Experimentla and clinical study of the development of spasm of the cerebral arteries related to subarachnoid hemorrhage. J Neurosurg 1970; 32: 617–625.

    Article  PubMed  CAS  Google Scholar 

  9. Weir B, Erasmo R, Miller J. Vasospasm in response to repeated subarachnoid hemorrhages in the monkey. J Neurosurg 1970; 23: 395–406.

    Google Scholar 

  10. Wilkins RH, Levitt P. Intracranial arterial spasm in the dog. A chronic experimental model. J Neurosurg 1970; 33: 260–269.

    PubMed  CAS  Google Scholar 

  11. Echlin FA: Current concepts in the etiology and treatment of vasospasm. Clin Neurousurg 1968; 15: 133–160.

    CAS  Google Scholar 

  12. Osterholm JL, Meyer R. Experimental effects of free serotonin on the brain and its relation to brain injury. Part 2: Trauma-induced alterations in spinal fluid and brain. J Neurosurg 1969; 31: 413–416.

    PubMed  CAS  Google Scholar 

  13. Wilkins RH, Odom GL. Intracranial arterial spasm associated with craniocerebral trauma. J Neurosurg 1970; 32: 626–633.

    PubMed  CAS  Google Scholar 

  14. Kuwayama A, Zervas NT. Belson R, Shintani A, Pickren K. A model for experimental cerebral arterial spasm. Stroke 1972; 3: 49–56.

    PubMed  CAS  Google Scholar 

  15. Varsos VG, Liszczak TM, Han DH, Kistler JP, Vielma J, Black PM, Heros RC, Zervas NT. Delayed cerebral vasospasm is not reversible by aminophylline, nifed-ipine, or papaverine in a “two-hemorrhage” canine model. J Neurosurg 1983; 58: 11–17.

    PubMed  CAS  Google Scholar 

  16. Eldevik OP, Krisiansen K, Torvik A. Subarachnoid hemorrhage and cerebrovas-cular spasm. Morphological study of intracranial arteries based on animal experiments and human autopsies. J Neurosurg 1981; 55: 869–876.

    Article  PubMed  CAS  Google Scholar 

  17. Findlay JM, Weir BKA, Kanamaru K, Espinosa F. Arterial wall changes in cerebral vasospasm. Neurosurgery 1989; 25: 736–746.

    Article  PubMed  CAS  Google Scholar 

  18. Seifert V, Stolke D, Reale E. Ultrastructural changes of the basilar artery following experimental subarachnoid haemorrhage. Acta Neurochir (Wien) 1989; 100: 164–171.

    Article  CAS  Google Scholar 

  19. Nishziawa S. Controversial issues regarding pathophysiology of vasospasm: A review. In Macdonald RL, ed. Cerebral Vasospasm. Advances in Research and Treatment. Thieme, 2004: 103–105.

    Google Scholar 

  20. Peterson JW, Nishizawa S, Hackett JD, Bun T, Teramura A, Zervas NT: Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs. 1990; 21: 133–137.

    CAS  Google Scholar 

  21. Nishizawa S, Nezu N, Uemura K. Direct evidence for a key role of protein kinase C in the development of vasospasm after subarachnoid hemorrhage. J Neurosurg 1992; 76: 635–639. 103–105.

    PubMed  CAS  Google Scholar 

  22. Nishizawa S, Peterson JW, Shimoyama I, Iwasaki K, Uemura K. Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. Neurosurgery 1993; 32: 986–992.

    Article  PubMed  CAS  Google Scholar 

  23. Nishizawa S, Yamamoto S, Yokoyama T, Ryu H, Uemura K. Chronological changes of arterial diameter, cGMP, and protein kinase C in the development of vasospasm. Stroke 1995; 26: 1916–1921.

    PubMed  CAS  Google Scholar 

  24. Nishizawa S, Obara K, Nakayama K, Koide M, Yokoyama T, Yokota N, Ohta S. Protein kinase C δ and α are involved in the development of vasospasm after subarachnoid hemorrhage. Eur J Pharmacol 2000; 398: 113–119.

    Article  PubMed  CAS  Google Scholar 

  25. Nishizawa S, Obara K, Koide M, Nakayama K, Ohta S, Yokoyama T. Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. J Vasc Res 2003; 40: 168–179.

    Article  CAS  Google Scholar 

  26. Yamaguchi M, Zhou C, Heistad DD, Watanabe Y, Zhang JH. Gene transfer of extracellular superoxide dismutase failed to prevent cerebral vasospasm after experimental subarachnoid hemorrhage. Stroke 2004; 35: 2512–2517.

    Article  PubMed  CAS  Google Scholar 

  27. Yatsushige H, Yamaguchi M, zhou C, Calvert JW, Zhang JH. Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage. Stroke 2005; 36: 1538–1543.

    Article  PubMed  CAS  Google Scholar 

  28. Zhou C, Yamaguchi M, Coloban AR, Zhang JH. Role of p53 and apoptosis in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2005; 25: 572–582.

    Article  PubMed  CAS  Google Scholar 

  29. Nishizawa S, Peterson JW, Shimoyama I, Uemura K. Relation between protein kinase C and calmodulin systems in cerebrovascular contraction: nvestigation of the pathogenesis of vasospasm after subarachnoid hemorrhage. Neurosurgery 1992; 4: 711–716.

    Article  Google Scholar 

  30. Yamaguchi-Okada M, Nishizawa S, Koide M, Nonaka Y. Biomechanical and phe-notypic changes in the vasospastic canine basilar artery after subarachnoid hemorrhage. J Appl Physiol 2005; 99: 2045–2052.

    Article  PubMed  Google Scholar 

  31. Koide M, Nishizawa S, Ohta S, Yokoyama T, Namba H. Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase. Neurosurgery 2002; 51: 1468–1476.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Occupational and Environmental Health, Fukuoka, Japan

    Shigeru Nishizawa

Authors
  1. Shigeru Nishizawa
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen M.D.

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu M.D., Ph.D.

  3. Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Xiao-Ming Xu M.D., Ph.D.

  4. Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, CA, USA

    John H. Zhang M.D., Ph.D.

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© 2009 Humana Press, a part of Springer Science + Business Media, LLC

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Nishizawa, S. (2009). Double Blood-Injection Cerebral Vasospasm Canine Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_26

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  • DOI: https://doi.org/10.1007/978-1-60327-185-1_26

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-184-4

  • Online ISBN: 978-1-60327-185-1

  • eBook Packages: Springer Protocols

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