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Probing the RNA-Binding Proteome from Yeast to Man: Major Advances and Challenges

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Yeast Systems Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2049))

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Abstract

RNA-binding proteins are important for core cellular processes such as mRNA transcription, splicing, transport, translation, and degradation. Recently, hundreds of novel RNA-binders have been identified in vivo in various organisms and cell types. We discuss the RNA interactome capture technique which enabled this boost in identifying new RNA-binding proteins in eukaryotes. A focus of this chapter, however, is the presentation of different challenges and problems that need to be addressed to be able to understand the conserved mRNA-bound proteomes from yeast to man.

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Acknowledgments

B.M.B. wishes to thank Matthias Hentze for discussions and comments on the chapter.

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Authors and Affiliations

  1. Molecular Infection Biology, IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany

    Benedikt M. Beckmann

  2. Centre for Systems and Synthetic Biology (SynthSys), University of Edinburgh, Edinburgh, UK

    Sander Granneman

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  1. Benedikt M. Beckmann
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  2. Sander Granneman
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Correspondence to Benedikt M. Beckmann .

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Editors and Affiliations

  1. Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK

    Stephen G. Oliver

  2. Genetadi Biotech, Parque Tecnológico de Bizkaia, Biscay, Spain

    Juan I. Castrillo

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Beckmann, B.M., Granneman, S. (2019). Probing the RNA-Binding Proteome from Yeast to Man: Major Advances and Challenges. In: Oliver, S.G., Castrillo, J.I. (eds) Yeast Systems Biology. Methods in Molecular Biology, vol 2049. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9736-7_13

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  • DOI: https://doi.org/10.1007/978-1-4939-9736-7_13

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