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Neurotoxicity Biomarker Assay Development

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Stroke Biomarkers

Part of the book series: Neuromethods ((NM,volume 147))

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Abstract

Neurotoxicity biomarker concept implying NR2 peptide and antibodies is presented in experimental models of transient cerebral ischemia and intracerebral hematoma. Various platforms of NR2 peptide and antibodies assays are developed to improve diagnostic certainty of cerebral ischemia. The assay bench testing results and methods are described. There are automatic analyzer, ELISA, and point-of-care tests discussed for laboratory and bedside applications.

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Author information

Authors and Affiliations

  1. CIS Biotech, Inc., Atlanta, GA, USA

    Galina A. Izykenova & German A. Khunteev

  2. Department of Pharmaceutical Technology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

    Galina A. Izykenova & Ivan I. Krasnjuk

  3. Brain Biomarkers Research Lab, Emory Decatur Hospital, Emory Healthcare, Decatur, GA, USA

    Svetlana A. Dambinova

  4. Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

    Vladimir L. Beloborodov & Svetlana A. Dambinova

Authors
  1. Galina A. Izykenova
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  2. German A. Khunteev
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  3. Ivan I. Krasnjuk
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  4. Vladimir L. Beloborodov
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  5. Svetlana A. Dambinova
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Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, New Zealand

    Philip V. Peplow

  2. Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Lab, Los Alamos, NM, USA

    Bridget Martinez

  3. Brain Biomarkers Research Lab, Emory Decatur Hospital, Emory Healthcare, Decatur, GA, USA

    Svetlana A. Dambinova

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Izykenova, G.A., Khunteev, G.A., Krasnjuk, I.I., Beloborodov, V.L., Dambinova, S.A. (2020). Neurotoxicity Biomarker Assay Development. In: Peplow, P.V., Martinez, B., Dambinova, S.A. (eds) Stroke Biomarkers. Neuromethods, vol 147. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9682-7_10

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  • DOI: https://doi.org/10.1007/978-1-4939-9682-7_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9681-0

  • Online ISBN: 978-1-4939-9682-7

  • eBook Packages: Springer Protocols

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