Abstract
Dysfunctional feeding behavior has a bidirectional aspect, too little and too much. The former reflects restricted eating and, in extreme, becomes an eating disorder such as anorexia nervosa (AN). The latter reflects lack of restraint and leads to obesity and life-shortening metabolic syndrome. Both of these dysfunctions have proven extremely difficult to prevent or treat, and the use of animal models that have translational validity may be one of the most cost-effective ways of advancing. This chapter describes some of the laboratory protocols using rodents that are available to model human eating dysfunctions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Schaumberg K, Anderson DA, Anderson LM, Reilly EE, Gorrell S (2016) Dietary restraint: what’s the harm? A review of the relationship between dietary restraint, weight trajectory and the development of eating pathology. Clin Obes 6:89–100
Berthoud HR, Münzberg H, Morrison CD (2017) Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms. Gastroenterology 152:1728–1738
Rossi MA, Stuber GD (2017) Overlapping brain circuits for homeostatic and hedonic feeding. Cell Metab 27(1):42–56
Martin B, Ji S, Maudsley S, Mattson MP (2010) “Control” laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A 107:6127–6133
Zorilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF (2005) Measuring meals: structure of prandial food and water intake of rats. Am J Physiol Regul Integr Comp Physiol 288:R1450–R1467
Kohsaka A, Laposky AD, Ramsay KM, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J (2007) High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 6:414–421
Avena NM, Bocarsly ME, Hoebel BG (2012) Animal models of sugar and fat bingeing: relationship to food addiction and increased body weight. Methods Mol Biol 829:351–365
Corwin RL, Avena NM, Boggiano MM (2011) Feeding and reward: perspectives from three rat models of binge eating. Physiol Behav 104:87–97
Mathes CM, Ferrara M, Rowland NE (2008) Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats. Am J Physiol Regul Integr Comp Physiol 295:R67–R75
Rowland NE, Crump EM, Nguyen N, Robertson K, Sun Z, Booth RG (2008) Effects of (−)-trans-PAT, a novel 5-HT2C agonist, on intake of palatable food in mice. Pharmacol Biochem Behav 91:176–180
Rowland NE, Cansler K, Kim E, Pawlik N, Robertson KL (2002) Flavor avoidance induced by LiCl and dexfenfluramine in rats and mice using nondeprivation protocols. Behav Neurosci 116:777–784
Chaix A, Zarrinpar A, Miu P, Panda A (2014) Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 20:991–1005
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA et al (2017) Every-other-day feeding extends life span but fails to delay many symptoms of aging in mice. Nat Commun 8:155
Méquinion M, Chauveau C, Viltart O (2015) The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients. Front Endocrinol (Lausanne) 6:68
Gutierrz E (2013) A rat in the labyrinth of anorexia nervosa: contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa. Int J Eat Disord 46:289–301
Hursh SR, Raslear TG, Shurtleff D, Bauman R, Simmons L (1988) A cost-benefit analysis of demand for food. J Exp Anal Behav 50:419–440
Atalayer D, Rowland NE (2009) Meal patterns of mice under systematically varying approach and unit costs for food in a closed economy. Physiol Behav 98:85–93
Collier G, Hirsch E, Hamlin H (1972) The ecological determinants of reinforcement in the rat. Physiol Behav 9:705–716
Goulding EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH (2008) A robusrt automated system elucidates mouse home cage behavioral structure. Proc Natl Acad Sci U S A 105:20575–20582
Nguyen KP, O’Neal TJ, Bolundoro OA, White E, Kravitz AV (2016) Feeding experimentation device (FED): a flexible open-source device for measuring feeding behavior. J Neurosci Methods 267:108–114
Rowland NE, Minaya DM, Cervantez MR, Minervini V, Robertson KL (2015) Differences in temporal aspects of food acquisition between rats and two strains of mice in a closed operant economy. Am J Physiol Regul Integr Comp Physiol 309:R93–R108
Acknowledgments
I thank Kimberly L. Robertson for her long-standing help and insights in developing several of the protocols described in this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Rowland, N.E. (2019). Protocols Using Rodents to Model Eating Disorders in Humans. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 2011. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9554-7_18
Download citation
DOI: https://doi.org/10.1007/978-1-4939-9554-7_18
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-4939-9553-0
Online ISBN: 978-1-4939-9554-7
eBook Packages: Springer Protocols