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Methods for Evaluating the Interaction Between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction

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Psychiatric Disorders

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2011))

Abstract

The environmental enrichment (EE) paradigm has been evaluated as a means of counteracting some of the consequences of chronic stress in rodents as well as a model of protective environment against drug abuse development. In the present chapter, our main aim is to describe the models of EE and chronic social stress and how they can be applied jointly in order to evaluate the effects of early psychosocial stress in animals exposed of different environments (enriched environment or standard environment). Furthermore, both paradigms could be applied in animal models of nicotine addiction, so the guidelines for the application of a chronic oral nicotine treatment in mice will be described. The heterogeneity of the procedures carried out in different laboratories makes it interesting to specify their characteristics in order to obtain replicable and valid animal models.

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Acknowledgments

This work was supported by grants from “Ministerio de Economía y Competitividad (MINECO)” (Grant numbers: PSI2009-10410 and PSI2016-78763-P) and “Conselleria d’Educació i Ciència” from Generalitat Valenciana (Spain) (GVACOMP2010-273, PROMETEO/2011/048 and PROMETEOII/2015/020).

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Authors and Affiliations

  1. Department of Psychobiology, University of Valencia, Valencia, Spain

    Patricia Mesa-Gresa, Santiago Monleón, Concepción Vinader-Caerols & Rosa Redolat

  2. Universidad Internacional de Valencia, Valencia, Spain

    Aránzazu Duque

Authors
  1. Patricia Mesa-Gresa
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  2. Aránzazu Duque
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  3. Santiago Monleón
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  4. Concepción Vinader-Caerols
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  5. Rosa Redolat
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Corresponding author

Correspondence to Patricia Mesa-Gresa .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Firas H. Kobeissy

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Mesa-Gresa, P., Duque, A., Monleón, S., Vinader-Caerols, C., Redolat, R. (2019). Methods for Evaluating the Interaction Between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 2011. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9554-7_15

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  • DOI: https://doi.org/10.1007/978-1-4939-9554-7_15

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9553-0

  • Online ISBN: 978-1-4939-9554-7

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