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The Multifaceted S100A4 Protein in Cancer and Inflammation

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Book cover Calcium-Binding Proteins of the EF-Hand Superfamily

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1929))

Abstract

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been discovered as a potent factor implicated in various inflammation-associated diseases. S100A4 is involved in a range of biological functions such as angiogenesis, cell differentiation, apoptosis, motility, and invasion. Moreover, S100A4 is also a potent trigger of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions.

Indeed, the release of S100A4 upon stress and mainly its pro-inflammatory role emerges as the most decisive activity in disease development, such as rheumatoid arthritis (RA), systemic sclerosis (SSc) allergy, psoriasis, and cancer. In the scope of this review, we will focus on the role of S100A4 as a mediator of pro-inflammatory pathways and its associated biological processes involved in the pathogenesis of various human noncommunicable diseases (NCDs) including cancer.

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Authors and Affiliations

  1. Faculty of Health, Department of Neuroscience, Copenhagen University, Copenhagen, Denmark

    Noona Ambartsumian, Jörg Klingelhöfer & Mariam Grigorian

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  1. Noona Ambartsumian
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  2. Jörg Klingelhöfer
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  3. Mariam Grigorian
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Correspondence to Noona Ambartsumian .

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  1. Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich, Zürich, Switzerland

    Claus W. Heizmann

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Ambartsumian, N., Klingelhöfer, J., Grigorian, M. (2019). The Multifaceted S100A4 Protein in Cancer and Inflammation. In: Heizmann, C. (eds) Calcium-Binding Proteins of the EF-Hand Superfamily. Methods in Molecular Biology, vol 1929. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9030-6_22

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  • DOI: https://doi.org/10.1007/978-1-4939-9030-6_22

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