Abstract
Following massive hepatocyte ablation in zebrafish, biliary epithelial cells can extensively give rise to hepatocytes through liver progenitor cells (LPCs). The zebrafish liver injury model is an important system to elucidate the molecular mechanisms underlying LPC-driven liver regeneration. Here, we describe a chemical screening method using the zebrafish model for identifying small molecules that can modulate LPC-driven liver regeneration.
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Acknowledgments
We thank Jackie Russell, Mehwish Khaliq, and Michael Tsang for editing the manuscript. This study was supported by an NIH grant (DK101426) to D.S.
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Ko, S., Shin, D. (2019). Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration. In: Tanimizu, N. (eds) Hepatic Stem Cells . Methods in Molecular Biology, vol 1905. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8961-4_8
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DOI: https://doi.org/10.1007/978-1-4939-8961-4_8
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