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Methionine Dependence of Cancer and Aging pp 263–266Cite as

Methionine Restriction and Life-Span Extension

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1866))

Abstract

It has been known for almost a century that caloric restriction can extend the life span of rodents and many other types of animals. Approximately 25 years ago, it was found that a methionine-restricted (MR) diet could replace a caloric-restricted diet with the result of extending the life span of animals. This chapter summarizes the effects of MR on the reversal of diabetes, obesity, and other aspects of the metabolic syndrome, as well as extending the normal life span. The most effective way to restrict methionine in the body, using orally-delivered methioninase, is also explored.

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Authors and Affiliations

  1. AntiCancer, Inc., San Diego, CA, USA

    Robert M. Hoffman

  2. Department of Surgery, University of California, San Diego, CA, USA

    Robert M. Hoffman

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  1. Robert M. Hoffman
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Correspondence to Robert M. Hoffman .

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  1. AntiCancer, Inc., San Diego, CA, USA

    Robert M. Hoffman

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Hoffman, R.M. (2019). Methionine Restriction and Life-Span Extension. In: Hoffman, R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology, vol 1866. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8796-2_19

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  • DOI: https://doi.org/10.1007/978-1-4939-8796-2_19

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8795-5

  • Online ISBN: 978-1-4939-8796-2

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