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Retinal Degeneration pp 367–381Cite as

Cell-Based Therapy for Retinal Disease: The New Frontier

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1834))

Abstract

The availability of noninvasive high-resolution imaging technology, the immune-suppressive nature of the subretinal space, and the existence of surgical techniques that permit transplantation surgery to be a safe procedure all render the eye an ideal organ in which to begin cell-based therapy in the central nervous system. A number of early stage clinical trials are underway to assess the safety and feasibility of cell-based therapy for retinal blindness. Cell-based therapy using embryonic stem cell-derived differentiated cells (e.g., retinal pigment epithelium (RPE)), neural progenitor cells, photoreceptor precursors, and bone marrow-derived hematopoietic stem/progenitor cells has demonstrated successful rescue and/or replacement in preclinical models of human retinal degenerative disease. Additional research is needed to identify the mechanisms that control synapse formation/disjunction (to improve photoreceptor transplant efficacy), to identify factors that limit RPE survival in areas of geographic atrophy (to improve RPE transplant efficacy in eyes with age-related macular degeneration), and to identify factors that regulate immune surveillance of the subretinal space (to improve long-term photoreceptor and RPE transplant survival).

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Acknowledgments

This is supported in part by the Joseph J. & Marguerite DiSepio Retina Research Fund, the New Jersey Lions Eye Research Foundation, the Eng Family Foundation, and the National Eye Institute (EY021542).

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Authors and Affiliations

  1. Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ, USA

    Marco Zarbin

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  1. Marco Zarbin
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Editors and Affiliations

  1. Institute of Human Genetics, University of Regensburg, Regensburg, Germany

    Bernhard H. F. Weber

  2. Department of Ophthalmology, University of Cologne, Cologne, Germany

    Thomas Langmann

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Zarbin, M. (2019). Cell-Based Therapy for Retinal Disease: The New Frontier. In: Weber, B.H.F., Langmann, T. (eds) Retinal Degeneration. Methods in Molecular Biology, vol 1834. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-8669-9_23

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  • DOI: https://doi.org/10.1007/978-1-4939-8669-9_23

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-8668-2

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