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Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury

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Pre-Clinical and Clinical Methods in Brain Trauma Research

Part of the book series: Neuromethods ((NM,volume 139))

Abstract

CN-NINM technology represents a synthesis of a new noninvasive brain stimulation technique with applications in physical medicine, cognitive, and affective neurosciences. Our new stimulation method appears promising for the treatment of a full spectrum of movement disorders and for both attention and memory dysfunction associated with traumatic brain injury. The integrated CN-NINM therapy proposed here aims to restore function beyond traditionally expected limits by employing both newly developed therapeutic mechanisms for progressive physical and cognitive training while simultaneously applying brain stimulation through a portable neurostimulation device called the PoNS™. Based on our previous research and recent pilot data, we believe a rigorous in-clinic CN-NINM training program, followed by regular at-home exercises that will also be performed with CN-NINM, will simultaneously enhance, accelerate, and extend recovery from multiple impairments (e.g. movement, vision, speech, memory, attention, and mood), based on divergent but deeply interconnected neurophysiological mechanisms of neuroplasticity.

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Abbreviations

CN-NINM:

Cranial-nerve noninvasive neurostimulation

MS:

Multiple sclerosis

TBI:

Traumatic brain injury

TLNS:

Translingual neurostimulation

TNS:

Trigeminal nerve stimulation

VNS:

Vagal nerve stimulation

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Acknowledgments

This research is made possible by the additional efforts of Mitchell Tyler, Kim Skinner, Kurt Kaczmareck, Jannet Ruhland, and Georgia Corner.

Disclosure

The lead author has a financial interest in Advanced NeuroRehabilitation LLC and in Helius Medical Technologies, which both have intellectual property rights in the field of use reported in this article.

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Authors and Affiliations

  1. Department of Kinesiology, University of Wisconsin, Madison, WI, USA

    Yuri Danilov & Dafna Paltin

Authors
  1. Yuri Danilov
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  2. Dafna Paltin
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Editor information

Editors and Affiliations

  1. Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA

    Amit K. Srivastava

  2. Department of Pediatric Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA

    Charles S. Cox

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Danilov, Y., Paltin, D. (2018). Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury. In: Srivastava, A., Cox, C. (eds) Pre-Clinical and Clinical Methods in Brain Trauma Research. Neuromethods, vol 139. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8564-7_19

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  • DOI: https://doi.org/10.1007/978-1-4939-8564-7_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8563-0

  • Online ISBN: 978-1-4939-8564-7

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